1.基金项目

(1) 山西省基础研究计划项目，Aβ寡聚体抑制剂的开发及其跨血脑屏障研究，主持，2022-2024

(2) 留学人员科研资助项目，治疗阿尔茨海默病多功能药物分子的设计与开发，主持，2021-2024

(3) 山西省自然科学基金项目，纳米反应器中聚甲醛二甲醚的可控合成，主持，2018-2020

(4) 山西省回国留学人员科研资助项目，聚甲氧基甲缩醛的合成及性能评价，主持，2017-2020

(5) 横向项目，N-氨甲酰谷氨酸的制备方法，主持，2023-2028

2.代表性论文

(1) Cheng Zhao, Yi Rong , Shuyuan Shi , Wen-chao Gao , Chaofeng Zhang, A novel method for synthesizing authentic SARS-CoV-2 main protease, Protein Expression and Purification, 2024, 222:106531

(2) Yuting Wu, Qiang Liu, Shuangping Huang, Chaofeng Zhang, Wenlong Wei and Xing Li, Cu(OAc)2-catalyzed three-component cycloaddition of malonates, nitrosoarenes and alkenes: access to isoxazolidines, Organic & Biomolecular Chemistry, 2023, 21, 3669-3674

(3) Yi Rong, Chaofeng Zhang, Wen-Chao Gao, Cheng Zhao, Optimization of the expression of the main protease from SARS-CoV-2, Protein Expression and Purification, 2023, 203:106208

(4) Jiandong Zhang, Rui Dong, Xiaoxiao Yang, Lili Gao, Chaofeng Zhang, Fan Ren, Jing Li, Honghong Chang, Characterization of four diol dehydrogenases for enantioselective synthesis of chiral vicinal diols, Chinese. J. Chem. Eng., 2022，47: 145-154

(5) Chaofeng Zhang, Tonglu Zhang, Jing Zhang, Jiandong Zhang, Ruifeng Li, Controllable synthesis of polyoxymethylene dimethyl ethers by ionic liquids encapsulated in mesoporous SBA-16, Chinese. J. Chem. Eng., 2021, 32: 175-182

(6) Jiandong Zhang, Ning Qi, Lili Gao, Jing Li, Chaofeng Zhang, Honghong Chang, One-pot synthesis of (R)- and (S)-phenylglycinol from bio-based L-phenylalanine by an artificial biocatalytic cascade, Bioresource and Bioprocessing, 2021, 8: 97-112

(7) Jian-Dong Zhang, Ya-Wen Chang, Rui Dong, Xiao-Xiao Yang, Li-Li Gao, Jing Li, Shuang-Ping Huang, Xing-Mei Guo, Chao-Feng Zhang and Hong-Hong Chang，Enantioselective Cascade Biocatalysis for Deracemization of Racemic β-Amino Alcohols to Enantiopure (S)-β-Amino Alcohols Employing Cyclohexylamine Oxidase and ω-Transaminase, ChemBioChem，2021, 22: 124-128

(8) Chaofeng Zhang, Yaozong Yang, Linfeng Li, Jiandong Zhang, Shuangping Huang, Ruifeng Li, Ionic Liquid Encapsulated in MIL-100 (Fe): A Green Catalyst for Synthesis of Polyoxymethylene Dimethyl Ethers from Methanol and Trioxane, Ind. Eng. Chem. Res, 2020, 59: 17094-17012

(9) Jiandong Zhang, Xiaoxiao Yang, Rui Dong, Lili Gao, Jing Li, Xing Li, Shuangping Huang, Chaofeng Zhang, and Honghong Chang，Cascade Biocatalysis for Regio- and Stereoselective Aminohydroxylation of Styrenyl Olefins to Enantiopure Arylglycinols，ACS Sustainable Chem. Eng., 2020, 8, 18277-18285

(10) Ya-Wen Chang, Jian-Dong Zhang, Xiao-Xiao Yang, Jing Li, Li-Li Gao, Shuang-Ping Huang, Xing-Mei Guo, Chao-Feng Zhang, Hong-Hong Chang, Jian-He Xu，High throughput solid-phase screening of bacteria with cyclic amino alcohol deamination activity for enantioselective synthesis of chiral cyclic β-amino alcohols, Biotechnol Lett, 2020, 42:1501–1511

(11) Chaofeng Zhang, Luiza M.F. Gomes, Tonglu Zhang, and Tim Storr, A small bifunctional chelator that modulates Aβ42 aggregation, Can. J. Chem.，2018, 96: 78-82

(12) Jian-Dong Zhang, Hua-Lei Wu, Tong Meng, Chao-Feng Zhang, Xiao-Jun Fan, Hong-Hong Chang, Wen-Long Wei. A high-throughput microtiter plate assay for the discovery of active and enantioselective amino alcohol-specific transaminases, Anal Biochem, 2017, 518: 94-101

(13) Hua-Lei Wu, Jian-Dong Zhang, Chao-Feng Zhang, Xiao-Jun Fan, Hong-Hong Chang, Wen-Long Wei, Characterization of Four New Distinct ω-Transaminases from Pseudomonas putida NBRC 14164 for Kinetic Resolution of Racemic Amines and Amino Alcohols, Appl Biochem Biotechnol, 2017, 181:972–985

(14) Chao-Feng Zhang, Shao-Jin Han,Yan-Bo Wu, Hai-Gang Lu, Gang Lu, Thermodynamic Stability versus Kinetic Stability: Is the Planar Hexacoordinate Carbon Species D3h CN3Mg3+ Viable? Journal of Physical Chemistry A, J. Phys. Chem. A, 2014, 118: 3319 -3325

(15) Chaofeng Zhang, Li Fan, Pin Yang. Study of the interaction of Zn2+ with Aβ (10-21) by fluorescamine assay. Chinese Chem Lett, 2007, 18: 97-98

(16) Yue-Jun Fu, Li-Tian Yin, Ai-Hua Liang, Chao-Feng Zhang, Wei Wang, Bao-Feng Chai, J.Y. Yang, Xiao-Jun Fan. Therapeutic potential of chlorotoxin-like neurotoxin from the Chinese scorpion for human gliomas. Neurosci Lett, 2007, 412: 62-67

(17) Chaofeng Zhang, Li Fan, Pin Yang. Study of the interaction of unaggregated and aggregated amyloid β protein (10-21) with outward potassium channel, Sci China Ser B, 2007, 50(5): 683-691

(18) Hui-Zhi Du，Chao-Feng Zhang，Miao-Yu Li，Pin Yang, 3-benzidino-6 (4-chlorophenyl) pyridazine blocks delayed rectifier and transient outward potassium current in acutely isolated rat hippocampal pyramidal neurons. Neurosci Lett, 2006, 402: 159-163

(19) Chao-Feng Zhang, Pin Yang. Zinc-induced aggregation of Aβ (10-21) potentiates its action on voltage-gated potassium channel. Biochem Biophys Res Co, 2006, 345: 43-49

(20) Chaofeng Zhang，Huizhi Du, Pin Yang. Effects of lithium chloride on outward potassium currents in acutely isolated hippocampal CA1 pyramidal neurons. Chinese Sci Bull, 2006, 51(16): 1961-1966

3.授权专利

(1) 张朝峰 黄双平 杨耀宗 张静 李瑞丰，一种MOFs封装离子液体催化剂及其制备和应用，中国，ZL 201811049073.4

(2) 张朝峰 李静 张桐露 杨耀宗 李瑞丰，一种固载离子液体催化剂及其制备方法和应用，中国，ZL 201710793567.2

(3) 李瑞丰 张朝峰 李静 张桐露 杨耀宗，固载离子液体催化剂及其制备方法和应用，中国，ZL 201710793545.6

(4) 李彦威 王丽丽 邢俊德 刘强 张朝峰 常宏宏 李兴 魏文珑，一种通过高效液相色谱分析法测定利用邻硝基苯酚制备邻氨基苯酚收率的方法，中国，ZL 201611036335.4

(5) 李彦威 邢俊德 王丽丽 张照昱 张朝峰 常宏宏 李兴 魏文珑，一种1,2-二（2-噻吩基）乙烷的合成方法， 中国，ZL 201410372070.X

(6) 张朝峰 邢俊德 刘康军 朱志红 王建忠 李瑞丰， 一种磁性纳米咪唑离子液体催化剂及其催化合成聚甲醛二甲醚的方法，中国，ZL 201310317367.1

(7) 张朝峰 李静 陈树伟 张海新 朱志红 王建忠 李瑞丰，一种分子筛负载离子液体催化剂及其催化合成聚甲醛二甲醚的方法，中国，ZL 201310314411.3

(8) 邢俊德 张朝峰 张照昱 李瑜 魏文珑 常宏宏 李兴，一种2-噻吩乙胺的合成方法，中国，ZL 201310215988.9

(9) 张朝峰 李兴 张帆 常宏宏，利用羧酸对环己基氮杂环丙烷开环的方法，中国，ZL 201210386427.0

(10) 张朝峰 李兴 张帆 常宏宏，基于对硝基苯甲酸的氮杂环丙烷化合物开环方法，中国，ZL 201210386433.6

4.学术奖励

2010年获山西省科学技术奖自然科学类二等奖