课题组以医药化学品合成与工艺开发为主线，围绕基于绿色环保医药化学品及中间体的小试合成方法研究、基于本质安全医药化学品及中间体的中试放大工艺开发两个研究方向开展基础及应用研究。

1.基金项目

(1) 山西省自然科学基金面上项目，No. 2015011023，煤沥青的乳化原理及过程调控研究，主持，201501-201712

(2) 煤转化国家重点实验室开放基金, No. J19-20-906, 乙二醇和苯胺合成吲哚的反应机理和控制过程研究, 主持，201901-202012

(3) 山西省自然科学基金面上项目, No. 201901D111080, 乙二醇和苯胺合成吲哚的反应机理和控制过程研究, 主持，201909-202209

(4) 山西省自然科学基金面上项目, No. 202303021211033, 表面亲疏水调控性负载催化剂的构建及其在煤基乙二醇转化合成吲哚中的应用, 主持，202401-202612

(5) 横向项目，葡萄糖酰化衍生物标准样品的制备，主持，201210-201402

(6) 横向项目，葡萄糖酰化衍生物分析方法的建立及分析测试，中国科学院山西煤炭化学研究所，主持，201210-201402

(7) 横向项目，D-氨基葡萄糖衍生物标准样品的制备，主持，201210-201402

(8) 横向项目，碳纳米管表面印迹复合材料的制备及其在化妆品中苯酚类化合物分析中的应用，主持，201307-201507

(9) 横向项目，以乙二醇和苯胺为原料合成吲哚，主持，202101-202512

2.代表性论文

(1) Honghong Chang, Haochun Zhang, Zhigang Jia , Xing Li, Wenchao Gao*, WenLong Wei*. Wettability of coal pitch surface by aqueous solutions of cationic Gemini surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016, 494:59-64.

(2) Honghong Chang, Yuan Wang, Yong Cui, Guojin Li, Bing Zhang*, Xiaoxia Zhao, Wenlong Wei*. Equilibrium and dynamic surface tension properties of Gemini quaternary ammonium salt surfactants with hydroxyl. Colloids and Surfaces A: Physicochemical and Engineering Aspects,2016, 500:230-238.

(3) Hong-Hong Chang, Fei Hu, Wen-Chao Gao*, Tao Liu, Xing Li, Wen-Long Wei, Yan Qiao*. Iodine-Mediated Oxidative Dehydrogenation of β-Acylamino Ketones for the Highly Stereoselective Synthesis of (Z)-β-Ketoenamides. Synlett, 2016, 27:1592-1596.

(4) Honghong Chang, Yong Cui, Yuan Wang, Guojin Li, Wenchao Gao*, Xing Li, Xiaoxia Zhao, Wenlong Wei*. Wettability and Adsorption of PTFE and Paraffin surfaces by aqueous solutions of biquaternary ammonium salt Gemini surfactants with hydroxyl. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016, 506:416-424.

(5) Honghong Chang, Haochun Zhang, Jia Lv, Bing Zhang, Wenlong Wei, Jingang Guo. Pt NPs and DNA zyme functionalized polymer nanospheres as triple signal amplification strategy for highly sensitive electrochemical immunosensor of tumour marker. Biosensors and Bioelectronics, 2016, 86:156–163.

(6) Xiaorong Gao, Yuan Wang, Xiaoxia Zhao, Wenlong Wei, Honghong Chang*. Equilibrium and dynamic surface tension properties of Gemini quaternary ammonium salt surfactants with ester groups. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016, 509:130-139.

(7) Wen-Chao Gao,* Fei Hu, Jun Tian, Xing Li, Wen-Long Wei, Hong-Hong Chang*. Hypoiodite-catalysed oxidative cyclisation of Michael adducts of chalcones with 1,3-dicarbonyl compounds: a facile and versatile approach to substituted furans and cyclopropanes. Chemical Communications, 2016, 52:13097-13100.

(8) Wen-Chao Gao, Tao Liu, Bing Zhang, Xing Li, Wen-Long Wei, Qiang Liu, Jun Tian*, Hong-Hong Chang*. Synthesis of 3-Sulfenylated Coumarins: BF3·Et2O‑Mediated Electrophilic Cyclization of Aryl Alkynoates Using N-Sulfanylsuccinimides. Journal of Organic Chemistry, 2016, 81: 1129711304.

(9) Honghong Chang, Jia Lv, Haochun Zhang, Bing Zhang*, Wenlong Wei, Yan Qiao*.Photoresponsive colorimetric immunoassay based on chitosan modified AgI/TiO2 heterojunction for highly sensitive chloramphenicol detection. Biosensors and Bioelectronics, 2017, 87: 579-586.

(10) 高晓荣，崔勇，赵晓霞，魏文珑，常宏宏*. 羟基和酯基型Gemini 双季铵盐表面活性剂在煤沥青表面的润湿特性. 化工学报，2017，68（1）：230-237.

(11) Honghong Chang*, Yong Cui, Wenlong Wei,Xing Li , Wenchao Gao, Xiaoxia Zhao, Shu Yin*. Adsorption Behavior and Wettability by Gemini Surfactants with Ester Bond at Polymer-Solution-Air Systems. Journal of Molecular Liquids, 2017, 230:429-436.

(12) Bing Zhang*, Hongyun Meng, Xue Wang, Honghong Chang*, Wenlong Wei. Bio-dye sensitized detection of Hg2+ based GO-ZnO-CdS nanohybrids. Sensors and Actuators B: Chemical, 2017, 253:495-501.

(13) Xue Wang, Bing Zhang*, Jing Li, Honghong Chang*, Wenlong Wei. A simple and fast chromogenic reaction based on Ag3PO4/Ag nanocomposite for tumor marker detection. Talanta, 2017, 175:229–234.

(14) Zhi-Mei Cui, Jian-Dong Zhang*, Xiao-Jun Fan, Gao-Wei Zheng Hong-Hong Chang*, Wen-Long Wei. Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-phenyl-1, 2-ethanediol by two substrate tolerance carbonyl reductases with cofactor regeneration. Journal of Biotechnology. 2017, 243:1-9.

(15) Bing Zhang, Hongyun Meng, Xue Wang, Jing Li, Honghong Chang, Wenlong Wei. Fe3+ doped ZnO-Ag photocatalyst for photoelectrochemical sensingplatform of ultrasensitive Hg2+ detection using exonuclease III-assisted target recycling and DNAzyme-catalyzed amplification. Sensors and Actuators B: Chemical, 2018, 255:2531-2537.

(16) Xiaorong Gao, Honghong Chang*, Yusuke Asakura, Zhihuan Zhao, Wenchao Gao, Yan Qiao*, Shu Yin*. Influence of water-controlled release process on the physical and chemical property of nanosize TiO2 particles. Materials Research Express, 2019, 6, 066208

(17) Juan Zhang, Mengjiao Gao, Wenchao Gao, Peng Yang, Fanhui Meng, Qiang Liu*, Honghong Chang*, Functional silver nanoparticles as broad-spectrum antimicrobial agents, New Journal of Chemistry, 2022, 46, 16387-16393.

(18) Xiaofeng Guo, Zhiwei Xue, Dongdong Xu, Qidong Tu, Honghong Chang*, Xihua Yang*, Shuangping Huang*, Total synthesis of (–)-brazilane via a lipase-catalyzed desymmetrisation reaction, Natural Product Research, 2022, 36(20): 5125-5133.

(19) Juan Zhang,* Zhi-Guang Ma, Yu Tian, Wei Li, Wen-Chao Gao, Hong-Hong Chang*, Divergent Synthesis of Fluorinated Alkenes, Allenes, and Enynes via Reaction of 2-Trifluoromethyl-1,3-enynes with Carbon Nucleophiles, Journal of Organic Chemistry, 2022, 87, 15086-15100.

(20) 田钰, 张娟, 高文超, 常宏宏*, 二甲亚砜作为甲基化试剂在有机合成中的应用, 有机化学，2023, 43(7), 2391-2406 (封面文章)

(21) 张娟, 王奕森, 田钰, 徐晶, 高文超, 常宏宏*, 孟凡会*, 杨朋*, 基于 DMSO-(d6)实现吲哚 C2-位的甲硫基与三氘甲硫基化反应, 有机化学, 2024, 44 (5): 1576-1583.

(22) Yu Wei, Yingxia Wu, Xuejin Li, Juan Zhang, Honghong Chang *, Wenchao Gao, Fanhui Meng*, Peng Yang *, Synthesis of indoles by dehydrodehydration and dehydration of aniline and ethylene glycol over Pt-based alumina catalysts, Journal of Organometallic Chemistry, 2024, 1011:123112.

(23) Jiangtao Liu, Xue Han, Liuping Yu, Jiandong Zhang, Shuangping Huang*, Xihua Yang*, Honghong Chang*, Chemoenzymatic formal synthesis of (+)-brazilin, Natural Product Research, doi.org/10.1080/14786419.2024.2349255

3.授权专利

(1) 第一发明人，一种煤沥青水浆及其制备方法，专利号：ZL200610048319.7

(2) 第一发明人，一种氯气捕消粉的制备方法，专利号：ZL201010149353.X

(3) 第一发明人，一种氯气捕消剂的制备方法，专利号：ZL201010145700.1

(4) 第一发明人，一种煤制乙二醇和苯胺合成吲哚的方法，专利号：201910347084.9

(5) 第一发明人，一种负载型催化剂及其制备方法和在催化乙二醇和苯胺合成吲哚中应用，专利号：201911366406.0

(6) 第一发明人，吲哚衍生物-银复合纳米颗粒及其制备方法和作为抑菌材料的应用，专利号：202110748950.2

(7) 第一发明人，一种N-甲基吲哚的合成方法，专利号：202111044996.2

(8) 第一发明人，单氟化4H-吡喃化合物及其合成方法，专利号：202210816049.9

4.出版专著

煤沥青粉和煤沥青水浆的制备技术. 国防工业出版社，2014

5.学术奖励

(1) 2023年获山西省自然科学三等奖，排名3；

(2) 2008年获山西省科技进步二等奖，排名5.