课题组聚焦合成药物化学中含硫分子的精准构筑和功能链接等问题，利用光催化或者金属催化策略，开展连接策略和功能模块的合成开发与应用，目前已在J. Am. Chem. Soc., ACS catal, Chem. Sci., Org.Lett.等国内外刊物发表研究论文三十余篇，授权发明专利十余项，实现转化两项。课题组研究成果和主页参见https://www.x-mol.com/groups/gaowenchao/publications
1.基金项目
(1) 国家自然科学基金(青年)项目, No.21901179,炔基硫亲电试剂的设计合成及其参与的炔基硫醚，炔基二硫醚的合成反应研究, 主持
(2) 山西省基础研究(新冠防治专项)项目, No. 202103021224067, 基于新冠COVID-19病毒3CL蛋白靶点的亲电硫多肽药物的设计与开发, 主持
(3) 山西省留学回国人员择优资助（重点）项目， No. 20200002, 基于DELs库及PROTACs分子库的含硫连接子的构建和调控,主持
(4) 中国博士后科学基金项目, No.2019M651424, 可回收亲电硫试剂的研制及其促进的串联环化反应研究, 主持
(5) 山西省重点研发计划（国际合作）项目No.201803D421093, 基于（流动）电化学反应的新型氧化还原介质的设计和开发, 主持
2.代表性论文
(1) Synthesis of Unsymmetrical Disulfides via Photocatalytic Hydrodisulfuration, Qi-Rui Dong, Yi-Sen Wang, Juan Zhang, Hong-Hong Chang, Jun Tian, and Wen-Chao Gao*, ACS Catal. 2024, 14, 18237−18246.
(2) Radical Alkynylthiolation with Visible-Light-Sensitive S-Alkynylthio Sulfonates, Yaonan Xue, Qirui Dong, Jiarui Chen, Hang Gao, Honghong Chang, Jun Tian, Wen-Chao Gao*, Org.Lett. 2024, 26, 6966–6971.
(3) N-Vinylthio Phthalimides (N-VTPs): Modular Reagents for Vinylthio AIEgen Transfer, Wen-Chao Gao*, Jing Fan, Ya-Feng Wei, Juan Zhang, Hong-Hong Chang, and Jun Tian*, Org.Lett. 2024, 26, 78-83.
(4) Structure-guided design and photochemical synthesis of new carbamo(dithioperoxo)thioates with improved potencies to SARS-CoV-2 3CLpro, De-Hang Yin, Jie Xin, Shizhao Chen, Shuai-Shuai Li , Zi-Ying Li , Jin-Xi Meng, Yue-Chi Lin, Bing-Qian Yin, Cheng Zhao, Jia Li, Hang Gao,* Jun Tian, Wen-Chao Gao*, Bioorganic & Medicinal Chemistry, 2024, 114, 11790.
(5) Construction of alkynyl and acyl disulfides directly through thiol-modification with N-alkynylthio phthalimides under acid catalysis, Yao-Nan Xue, Kai Feng, Jun Tian, Juan Zhang, Hong-Hong Chang, Wen-Chao Gao* , Org. Chem. Front. 2023, 10 , 2070-2074.
(6) N-Acetylenethio phthalimides: sequential linkage for compositional click reaction, Wen-Chao Gao*, Kai Feng, Jun Tian, Juan Zhang, Hong-Hong Chang, Xuefeng Jiang*, Chin.Chem. Lett. 2023, 34, 107587.
(7) N-Thiohydroxy Succinimide Esters (NTSEs)：Versatile Reagents for Selective Acyl and Acylthio Transfer, Yun-Feng Li, Ya-Feng Wei, Jun Tian, Juan Zhang, Hong-Hong Chang, Wen-Chao Gao*, Org. Lett. 2022, 24, 5736-5740.
(8) Recent Advances in thiolation via sulfur electrophiles, Ya-Feng Wei, Wen-Chao Gao* , Hong-Hong Chang, Xuefeng Jiang *, Org. Chem. Front. 2022, 9, 6684-6707.
(9) 3,4-Bisthiolated Pyrroles: Concise Construction and Their Electronic Properties, Jun Tian, Kai Feng, Kang-Ning Yuan, Xing Li, Hong-Hong Chang, Wen-Chao Gao*, J. Org. Chem. 2022, 87, 2402–2409.
(10) 3-Thiolated pyrroles/pyrrolines: controllable synthesis and usage for the construction of thiolated fluorophores, Jun Tian, Kang-Ning Yuan, Wen Liu, Hong-Hong Chang, Xing Li, Wen-Chao Gao*, Chem. Commun. 2021, 57, 1943-1946.
(11)Rh(I)-Catalyzed Carbene Migration/Carbonylation/Cyclization: Straightforward Construction of Fully Substituted Aryne Precursors, Guohao Zhu, Wen-Chao Gao, Xuefeng Jiang*, J. Am. Chem. Soc. 2021, 143, 1334-1340.
(12) Steric and Stereoscopic Disulfide Construction for Cross-linkage via N-Dithiophthalimides, Wen-Chao Gao, Jun Tian, Yuzhu Shang, Xuefeng Jiang*, Chem. Sci. 2020, 11, 3903-3908.
3.授权专利
(1) 高文超，尚玉柱，田俊，常宏宏. 一种N-炔硫基邻苯二甲酰亚胺类化合物的制备方法。专利授权号：ZL 2019 1 0440132.9.
(2) 姜雪峰，高文超. 立体和大位阻二硫醚化合物及其合成方法和应用。专利授权号：ZL 2020 1 0185510.6
(3) 高文超，田俊，常宏宏，张娟. 一种3,4-双硫代吡咯材料的制备方法.专利授权号：ZL 2021 1 1126551.9.
4.学术奖励
2022年，山西省自然科学三等奖（2022-Z-3-001）（第1完成人）
