1.基金项目
(1) 国家自然科学基金面上项目，No. 22171207, 生物催化烯烃不对称氢胺化构筑手性胺研究，主持，2022-2025
(2) 国家自然科学基金面上项目，No. 21772141，生物催化烯烃不对称胺羟化构建手性β-氨基醇及协同机制探究，主持，2018-2021
(3) 山西省自然科学青年基金，No. 201701D221042，转氨酶分子改造不对称氨化羟酮合成手性邻氨基醇的性能及其构效关系研究，主持，2017-2019
(4) 山西省高等学校科技创新项目，No. 2015132，手性邻氨基醇合成用酶的定向筛选及其催化性能的研究，主持，2015-2017。
2.代表性论文
(1) Jingqi Zhang, Hang Gao, Lili Gao*, Mengyi Chen, Shuangping Huang and Jiandong Zhang. Biocatalytic Asymmetric Ring-Opening of meso-Epoxides to Enantiopure Cyclic trans-ß-Amino Alcohols Involving a Key Amine Transaminase. Green Chemistry, 2024, 26, 6160–6171.
(2) Rui-Yan Zhao, Shuang-Ping Huang, Li-Li Gao, Jian-Dong Zhang. One-Pot Biocatalytic Upgrading Lignin-Derived Phenol and Catechol to Hydroxytyrosol. Green Chemistry, 2024, 26, 6180–6189.
(3) Yin-Hua Suo, Jing-Qi Zhang, Ning Qi, Shuang-Ping Huang, Hang Gao, Li-Li Gao, Chao-Feng Zhang, Yu-Cai He, Jian-Dong Zhang. One-Pot Two-stage biocatalytic upgrading of biomass-derived aldehydes to optically active β-amino alcohols via sequential hydroxymethylation and asymmetric reduction amination. Green Chemistry, 2024, 26, 927-935.
(4) Qi Jin, Jingqi Zhang, Shuangping Huang, Lili Gao, Honghong Chang, Jiandong Zhang*. Biocatalytic formal regio- and enantioselective Markovnikov hydroamination of aryl alkenes to chiral amines. Green Chemistry, 2023, 25, 4840–4848.
(5) Jiandong Zhang, Xiaoxiao Yang, Rui Dong, Lili Gao, Jing Li, Xing Li, Shuangping Huang, Chaofeng Zhang, Honghong Chang. Cascade Biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols. ACS Sustainable Chem. Eng. 2020, 8: 18277-18285.
(6) Zhi-Mei Cui, Jian-Dong Zhang, Xiao-Jun Fan, Gao-Wei Zheng Hong-Hong Chang*, Wen-Long Wei. Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-phenyl-1, 2-ethanediol by two substrate tolerance carbonyl reductases with cofactor regeneration. Journal of Biotechnology. 2017, 243: 1–9.
(7) Jian-Dong Zhang, Xiao-Xiao Yang, Qiao Jia, Jian-Wei Zhao, Li-Li Gao, When-Chao Gao, Hong-Hong Chang, Wen-Long Wei and Jian-He Xu. Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system. Catal. Sci. Technol., 2019, 9, 70-74.
(8) Jian-Dong Zhang, Shuke Wu, Jinchuan Wu, Zhi Li. Enantioselective Cascade Biocatalysis via Epoxide Hydrolysis and Alcohol Oxidation: One-Pot Synthesis of (R)-α-Hydroxy Ketones from Meso- or Racemic Epoxides. ACS Catalysis. 2015,5:51-58.
3.学术报告
(1) 张建栋，一锅生物催化木质素衍生苯酚和儿茶酚合成高附加值羟基酪醇，中国化学会34届年会，口头报告，广州，2024年6月16日。
(2) 张建栋，生物催化芳基烯烃不对称Markovnikov氢胺化合成手性胺的研究，2023生物工程学会第六届青年科技论坛，口头报告，乌鲁木齐，2023年8月21日。
