1.基金项目
(1)国家自然科学基金青年项目,活性氧响应性溶酶体靶向多肽-聚合物的设计合成及其降解Aβ作用与机制研究,主持(No. 22207082)
(2)山西省基础研究计划(自由探索类)青年项目,铈掺杂碳点对淀粉样蛋白聚集的多功能诊疗作用,主持(No. 202103021223118)
(3)国家自然科学基金面上项目,设计多功能纳米马达强化对β淀粉样蛋白的解毒作用,参与(No. 21978207)
(4)天津市自然科学基金项目,基于人白蛋白构筑淀粉样β多肽聚集的多功能抑制剂,参与(No. 19JCZDJC36800)
2.代表性论文
(1) Wang Wenjuan; Lin Xiaoding; Dong Xiaoyan; Sun Yan ; A multi-target theranostic nanocomposite against Alzheimer's disease fabricated by conjugating carbon dots and triplefunctionalized human serum albumin, Acta Biomaterialia, 2022, 148: 298-309.
(2) Wang Wenjuan; Zhao Guangfu; Dong Xiaoyan; Sun Yan ; Unexpected Function of a Heptapeptide-Conjugated Zwitterionic Polymer that Coassembles into β-Amyloid Fibrils and Eliminates the Amyloid Cytotoxicity, ACS Applied Materials & Interfaces, 2021, 13(15): 18089-18099.
(3) Wang Wenjuan; Liu Miaomiao; Gao Weiqun; Sun Yan; Dong Xiaoyan ; Coassembled Chitosan–Hyaluronic Acid Nanoparticles as a Theranostic Agent Targeting Alzheimer’s β-Amyloid, ACS Applied Materials & Interfaces, 2021, 13(47): 55879-55889.
(4) Wang Wenjuan; Liu Wei; Dong Xiaoyan; Sun Yan; Design of multifunctional agent based on basified serum albumin for efficient in vivo β-amyloid inhibition and imaging, ACS Applied Bio Materials, 2020, 3: 3365-3377.
(5) Wang Wenjuan; Dong Xiaoyan; Sun Yan; Modification of serum albumin by high conversion of carboxyl to amino groups creates a potent inhibitor of amyloid β-protein fibrillogenesis, Bioconjugate Chemistry, 2019, 30: 1477-1488.